Development Of Leptospira Antigen Panel For Scaling-Up Diagnosis Of Human And Animal Leptospirosis To Improve Productivity In Tanzania

Project Summary

Leptospirosis disease is caused by spirochete bacterium of the genus Leptospira is highly neglected in Africa where the disease infects about 100 people per 100,000 annually. The prevalence in humans in Tanzania range between 10-30%, whereas in animals is much higher up to 50% in various animal species. Despite these facts, leptospirosis is highly neglected and routine diagnosis is not done. The awareness of this disease is totally lacking in the medical community and the general public hence there is a need to increase public awareness and establishment of diagnosis of this disease in Tanzania.

The goal of this project is to gather evidence for leptospirosis prevalence in selected regions of Tanzania in addition to Morogoro region where leptospirosis is well documented in order to identify most common Leptospira serovars infecting humans and animals in Tanzania for development of a panel of leptospira antigens needed for diagnosis by gold standard microscopic agglutination test. Control of leptospirosis will improve public health, animal health and livestock productivity in Tanzania and in the region.

Project Duration

2015 – 2019

Prof. Apia W. Massawe

SUA (Tanzania)

Prof. RH Makundi

SUA (Tanzania)

Dr. GF Mgode

SUA (Tanzania)

Mashaka E. Mdangi


Christina Tewele


Prof. LS Mulungu

SUA (Tanzania)

Tanzania Commission for Science and Technology (COSTECH)

Amount: TZS89,726,963.00