Dr. Georgies Mgode
Sokoine University of Agriculture – Pest Management Center
Sokoine University of Agriculture
Pest Management Center
P.O. Box 3110
Email: firstname.lastname@example.org | email@example.com
Dr. Georgies Mgode is a Research Fellow at Pest Management Centre, Sokoine University of Agriculture (SPMC) heading the Vector-borne and Zoonotic Disease Studies Section. He is also the program manager of APOPO TB dealing with novel diagnosis of pulmonary tuberculosis (TB) using trained African giant pouched rats (Cricetomys sp. Swahili: Panyabuku). Dr. Mgode has research interest in tuberculosis and rodent borne zoonotic diseases including leptospirosis.
He is among the pioneer researchers of tuberculosis detection using rats and has explored the specific odour compounds (volatile organic compounds) of Mycobacterium tuberculosis detected by trained rats for doctoral degree studies at the Max Planck Institute for Infection Biology (MPIIB), in Berlin Germany. His work provided first insights on the specific odour compounds that rats detect to distinguish TB positive and negative patients.
In 2012 Dr. Mgode was awarded the presidential Medal of Invention and Scientific Research, from H.E. Jakaya Mrisho Kikwete, President of Tanzania for his novel research on TB diagnosis. For past 24 years he has been conducting research on leptospirosis a highly neglected rodent borne disease affecting humans and animals. His research focuses on mapping of leptospirosis burden domestic and wild animals and humans; understanding the commonly circulating Leptospira serovars for enhancing diagnosis and control strategies.
He described a new Leptospira serovar Sokoine that infects a broad range of domestic and wild animals, and humans which now a key antigen in serodiagnosis of leptospirosis in Tanzania. He is leading a high profile collaborative research on TB volatiles markers for potential developing a point-of care test for tuberculosis in high burden countries funded by UBS Optimus Foundation.
Max Planck Institute for Infection Biology/Technical University of Berlin, Germany.
University of Pretoria, South Africa.
The Open University of Tanzania, Tanzania.
LITI, Dar es Salaam, Tanzania.
Rodent-borne diseases and tuberculosis detection using trained rats
Dr. Georgies Mgode is a Research Fellow at Pest Management Centre, Sokoine University of Agriculture (SPMC) heading the Vector-borne and Zoonotic Disease Studies Section; and is the program manager of APOPO TB involved with novel diagnosis of pulmonary tuberculosis (TB) using trained African giant pouched rats (Cricetomys sp. Swahili: Panyabuku).
Dr. Mgode has research interest in tuberculosis and rodent borne zoonotic diseases including leptospirosis. He is among the pioneer researchers of tuberculosis detection using rats and he explored the specific odour compounds (volatile organic compounds) of Mycobacterium tuberculosis which are targeted by TB detection rats for doctoral degree studies at the Max Planck Institute for Infection Biology (MPIIB), in Berlin Germany.
His work provided first insights on the specific odour compounds that rats detect to distinguish TB positive and negative patients. In 2012 Dr. Mgode was awarded the presidential Medal of Invention and Scientific Research, from H.E. Jakaya Mrisho Kikwete, President of Tanzania for his novel research on TB diagnosis. For past 23 years he has been conducting research on leptospirosis a highly neglected rodent borne disease affecting humans and animals.
His research focuses on mapping of leptospirosis burden domestic and wild animals and humans; understanding the commonly circulating Leptospira serovars for enhancing diagnosis and control strategies funded by COSTECH.
His description of a new Leptospira serovar Sokoine that infects a broad range of domestic and wild animals, and humans contributes to the much-needed local antigens for serodiagnosis of leptospirosis in Tanzania where this disease in not routinely diagnosed. He is currently working towards development of Leptospira antigen panel for scaling-up diagnosis of human and animal leptospirosis to improve public health and livestock productivity in Tanzania and subsequently in other African countries with high prevalence of leptospirosis.
He is also conducting high profile collaborative researches on TB volatiles markers for potential point-of care testing of tuberculosis in high burden countries funded by UBS Optimus Foundation. Dr. Mgode is a member of the National Steering Committee for Public Health Pesticides; the National Malaria Vector Control Sub-committee (Tanzania), the International Leptospirosis society (ILS) and the African Leptospirosis Network.
Innovative and Enhanced TB Control in Dodoma and Morogoro Periphery (2017-2018). Funded by Swissand Germany Embassy: Co-Principal Investigator
Evaluation of Tuberculosis odour compounds in samples detected by trained rats (UBS Optimus Foundation, 2015-2017). Principal Investigator
Development of Leptospira antigen panel for scaling-up diagnosis of human and animal leptospirosis to improve productivity in Tanzania (Commission for Science and Technology (COSTECH) 2015-2017. Principal Investigator
Towards a TB Free Dar Es Salaam with T3: Test, Track and Treat (2016-2018). Funded by Human Development Innovation Fund (HDIF) under DFID. Co-PI and Program manager.
Training African giant pouched rats as a cheap tool for early diagnosis of Tuberculosis (ongoing program since 2013-2017). Funded by UBS Optimus Foundation. Co-Investigator, Program manager
Active Tuberculosis case finding in prisons population (2015-2016). Funded by USAID Developmen Innovation Ventures (DIV).Program manager (Tanzania). USD
80,000, Co-Principal Investigator
Role of rare mole rat species co-existing with humans in northern Tanzania in transmission of neglected zoonotic diseases (International Foundation for Science (IFS)-2015-2017). Principal Investigator
ACE II. African center of excellence for innovative rodent pest management and biosensor technology development. World Bank funded project. Project member, heading the biosensor technology section.
9.Tuberculosis detection by rats.
- Mgode GF, Cox CL, Mwimanzi S, Mulder C. Pediatric tuberculosis detection using trained African giant pouched rats. Pediatric research. 2018 Apr 4.
- Mirambo MM, Mgode GF, Malima ZO, John M, Mngumi EB, Mhamphi GG, Mshana SE. Seropostivity of Brucella spp. and Leptospira spp. antibodies among abattoir workers and meat vendors in the city of Mwanza, Tanzania: A call for one health approach control strategies. PLoS neglected tropical diseases. 2018 Jun 25;12(6):e0006600.
- Mulder, C., G. F. Mgode, H. Ellis, E. Valverde, N. Beyene, C. Cox, S. E. Reid, A. H. Van'tHoog, and T. L. Edwards. Accuracy of giant African pouched rats for diagnosing tuberculosis: comparison with culture and Xpert® MTB/RIF.The International Journal of Tuberculosis and Lung Disease 21, no. 11 (2017): 1127-1133.
- Katandukila, J. V., Ngalameno, M. K., Mgode, G., Bastos, A. D., & Bennett, N. C. (2017). Pattern of ovulation in an ancient, solitary mole-rat
lineage: Heliophobiusargenteocinereusemini from Tanzania. Canadian Journal of Zoology, (ja).
- Edwards, T. L., Ellis, H., Watkins, E. E., Mulder, C., Mgode, G., Cox, C., & Poling, A. (2017). TuberculosisDetection by Pouched Rats: Opportunities
for Reinforcement under Low-Prevalence Conditions. Behavioural Processes.
- Faulkes, C. G., Mgode, G. F., Archer, E. K., & Bennett, N. C. (2017). Relic populations of Fukomysmole-rats in Tanzania: description of two new species F.
livingstoni sp. nov.and F. hanangensis sp. nov.PeerJ, 5, e3214.
- Mulder, C., Mgode, G., & Reid, S. E. (2017). Tuberculosis diagnostic technology: an African solution… think rats. African Journal of Laboratory
Medicine, 6(2), 1-4.
- Poling, A., Valverde, E., Beyene, N., Mulder, C., Cox, C., Mgode, G., & Edwards, T. L. (2016). Active tuberculosis detection by pouched rats in
2014: More than 2,000 new patients found in two countries. Journal of
Applied Behavior Analysis.
- Mgode G, Cox C, Bwana D, Mtui L, Magesa D, Kahwa A, Mfinanga G, Mulder C. Enhancing tuberculosis detection by trained rats and tracking of missed patients through community-based strategy in TB high-burden countries. BMJ Global Health. 2017 Feb 1;2 (Suppl 2):A34-5.
- Mgode GF, Cox C, Mulder C, Valverde E, Mwesiga G, Maeda J. Detection Rats Technology for Diagnosis of Tuberculosis in High-Risk Populations. Huria: Journal of the Open University of Tanzania. 2016;22(1):35-41.
- Ngalameno, M. K., Bastos, A. D., Mgode, G., & Bennett, N. C. (2016). The pattern of reproduction in Heliophobius from Tanzania: do not refrain
during the long rains!.Canadian Journal of Zoology 95 (2):107-114.
- Mulungu L.S..Kapingu, E., Mgina, C. A., Mwatawala, M. W., Kichuki, M., Mwakalobo, A. S., &Mgode, G. F. (2016). Domestic Cat (Felissilvestriscatus) Urine Odour as a Potential Rodent Management Strategy. Huria: Journal of the Open University of Tanzania 22 (1), 132-139.
- Mgode, G.F., Machang’u, R.S., Mhamphi, G.G., Katakweba, A., Mulungu, L.S., Durnez, L., … & Belmain, S. R. (2015). Leptospira Serovars for Diagnosis of Leptospirosis in Humans and Animals in Africa: Common Leptospira Isolates and Reservoir Hosts. PLoS neglected tropical diseases, 9(12).
- Poling, A., Mahoney, A., Beyene, N., Mgode, G., Weetjens, B., Cox, C., & Durgin, A. (2015). Using giant African pouched rats to detect human tuberculosis: a review. The Pan African medical journal, 21.
- Georgies F. Mgode, Stephan Cohen-Bacrie, MarielleBedotto, Bart J. Weetjens, ChristopheCox, Maureen Jubitana, Dian Kuipers, Robert S. Machang’u, RudovickKazwala,Sayoki G. Mfinanga, Stefan H. E. Kaufmann (2015). Mycobacterium Genotypes in Pulmonary Tuberculosis Infections and Their Detection by Trained African Giant Pouched Rats.Current microbiology 70 (2), 212-218
- Georgies F. Mgode, Stephan Cohen-Bacrie, Marielle Bedotto, Bart J. Weetjens, Christophe Cox, Maureen Jubitana, Dian Kuipers, Robert S. Machang’u, Rudovick Kazwala, Sayoki G. Mfinanga, Stefan H. E. Kaufmann (2014). Mycobacterium Genotypes in Pulmonary Tuberculosis Infections and Their Detection by Trained African Giant Pouched Rats. Current Microbiology. DOI 10.1007/s00284-014-0705-6.
- Mgode GF, Katakweba AS, Mhamphi GG, Fwalo F, Mdangi M, Kilonzo BS & Mulungu LS. (2014) Prevalence of leptospirosis and toxoplasmosis: A study of rodents and shrews in cultivated and fallow land, Morogoro rural district, Tanzania. Tanzania Journal of Health Research 16 (3), 2014.
- Mgode, G. F., Mbugi, H. A., Mhamphi, G. G., Ndanga, D., & Nkwama, E. L. (2014). Seroprevalence of Leptospira infection in bats roosting in human settlements in Morogoro municipality in Tanzania. Tanzania Journal of Health Research, 16(1).
- Mgode, G. F., Mhamphi, G. G., Katakweba, A., & Thomas, M. (2014). Leptospira infections in freshwater fish in Morogoro Tanzania: a hidden public health threat. Tanzania Journal of Health Research, 16(2).
- Mgode GF, Weetjens BJ, Nawrath T, Lazar D, Cox C, Jubitana M, Mahoney A, Kuipers D, Machang’u RS, Weiner J, Schulz S, Kaufmann SHE. (2012) Mycobacterium tuberculosis volatiles for diagnosis of tuberculosis by Cricetomys rats. Tuberculosis 2012; 92: 535-542.
- Mgode GF, Weetjens BJ, Cox C, Jubitana M, Machang'u RS, Lazar D, Weiner J, Van Geertruyden JP, Kaufmann SH. (2012) Ability of Cricetomys rats to detect Mycobacterium tuberculosis and discriminate it from other microorganisms. Tuberculosis (Edinb). 2012 Mar;92(2):182-6. Epub 2011 Dec 24.
- Mgode GF, Weetjens BJ, Nawrath T, Cox C, Jubitana M, Machang'u RS, Cohen-Bacrie S, Bedotto M, Drancourt M, Schulz S, Kaufmann SH. (2012) Diagnosis of tuberculosis by trained African giant pouched rats and confounding impact of pathogens and microflora of the respiratory tract. J Clin Microbiol. 2012 Feb;50(2):274-80. Epub 2011 Nov 30.
- Thorben Nawrath, Georgies F. Mgode, Bart Weetjens, Stefan H. E. Kaufmann, Stefan Schulz (2012). The volatiles of pathogenic and nonpathogenic mycobacteria and related bacteria. Beilstein J Org Chem. 2012, 8, 290–299.
- Beyene N, Mahoney A, Cox C, Weetjens B, Makingi G, Mgode G, Poling A (2012). APOPO’s tuberculosis research agenda: achievements, challenges and prospects. Tanzania Journal of Health Research, 14(2).
- Mahoney AM, Weetjens BJ, Cox C, Beyene N, Mgode G, Jubitana M, Kuipers D, Kazwala R, Mfinanga GS, Durgin A, Poling A (2011). Using giant African pouched rats to detect tuberculosis in human sputum samples: 2010 findings. Pan Afr Med J. 2011;9:28. Epub 2011 Jul 18.
- C. G. Faulkes, N. C. Bennett, F. P. D. Cotterill, W. Stanley, G. F. Mgode, E. Verheyen (2011). Phylogeography and cryptic diversity of the solitary-dwelling silvery mole-rat, genus Heliophobius (family: Bathyergidae). J Zool 2011, 285 (4): 324-338. 10.1111/j.1469-7998.2011.00863.
- Georgies F. Mgode, Robert S. Machang’u, Margarida Collares-Pereira, Maria Luisa Vieira, Marga G. A. Goris, Mirjam Engelbert and Rudy A. Hartskeerl (2010). Challenges in determining the pathogenicity status of Leptospira isolates with phenotypic methods: The need for a polyvalent approach. Afr J Microbiol Res, 4 (23): 2528-2533.
- Chris G. Faulkes, Georgies F. Mgode, Steven C. Le Comber and Nigel C. Bennett (2010). Cladogenesis and endemism in Tanzanian mole-rats, genus Fukomys: (Rodentia: Bathyergidae): a role for tectonics? Biol J Linnean Soc, 100: 337–352.
- Alan Poling, Bart J. Weetjens, Christophe Cox, Georgies Mgode, Maureen Jubitana, Rudovic Kazwala, Godfrey S. Mfinanga, and Diana Huis in ‘t Veld (2010). Using Giant African Pouched Rats to Detect Tuberculosis in Human Sputum Samples: 2009 Findings. Am. J. Trop. Med. Hyg., 83(6): 1308-1310.
- Bart J Weetjens, Georgies Mgode, Witkind Davis, Christophe L Cox and Negussie W Beyene (2009). African giant rats for tuberculosis detection: a novel diagnostic technology. Global Forum Update on Research for Health Vol 6: 41.
- Weetjens B.J., G. F. Mgode, R. S. Machang’u, R. Kazwala, G. Mfinanga et al. (2009). African pouched rats for the detection of pulmonary tuberculosis in sputum samples. Int J Tuberc Lung Dis 13(6): 1–7.
- Makundi, Rhodes H. Apia W. Massawe, Loth S. Mulungu, Abdul Katakweba, Thomas J. Mbise and Georgies Mgode. (2008). Potential mammalian reservoirs in a bubonic plague outbreak focus in Mbulu District, northern Tanzania, in 2007. Mammalia 72: 253-257.
- Lies Durnez, Miriam Eddyani, Georgies F Mgode, Abdul Katakweba, Charles R Katholi, Robert R Machangu, Rudovick R Kazwala, Francoise Portaels, Herwig Leirs (2007). First findings of mycobacteria in African rodents and insectivores using stratified pool screening. Appl Environ Microbiol. 2007 Dec7:18065608.
- G.F. Mgode, R.S. Machang’u, M.G. Goris, M. Engelbert, S. Sondij and R.A. Hartskeerl (2006). New Leptospira serovar Sokoine of serogroup Icterohaemorrhagiae from cattle in Tanzania. Int J Systemat Evol Microbiol 56:593-597.
- G.F. Mgode, G. Mhamphi, A. Katakweba, E. Paemelaere, N. Willekens, H. Leirs, R.S. Machang’u and R.A. Hartskeerl (2005). PCR detection of Leptospira DNA in rodents and insectivores from Tanzania. Belg J Zool 135:17-19.
- Kilonzo, B., Mhina, J., Sabuni, C. and Mgode G (2005). The role of rodents and small carnivores in plague endemicity in Tanzania. Belg J Zool 135: 119-125.
- Machang'u, R. S., G. F. Mgode, J. Assenga, G. Mhamphi, B. Weetjens, C. Cox, R. Verhagen, S. Sondij, M.G. Goris,& R.A. Hartskeerl (2004). Serological and molecular characterization of Leptospira serovar Kenya from captive African giant pouched rats (Cricetomys gambianus) from Morogoro Tanzania. FEMS Immunol Med Microbiol 41:117-121.
- Machang’u R, Mgode G, Asenga J, Mhamphi G, Hartskeerl R, Goris M, Cox C, Weetjens B, Verhagen R (2003). Characterization of Leptospira isolates from captive giant pouched rats, Cricetomys gambianus. In: Rats, Mice and People, Rodent Biology and Management. Eds, Singleton, GR, Hinds, LA, Krebs, CJ, and Spratt, MD. Australian Centre for International Agricultural Research, Canberra, 2003.
- Kilonzo, B.S., Ngomuo, A.J., Sabuni, C.A., Mgode, G.F (2001). Effects of Azadirachta indica (Neem) extracts on livestock fleas in Morogoro district, Tanzania. Insect Sci. Applic. Vol. 21, No. 1.
- Machang'u RS, Mgode G, Mpanduji D. (1997). Leptospirosis in animals and humans in selected areas of Tanzania. Belg J Zool Vol. 127 (1): 97–104.
- Machang'u, R.S. Mgode, G. and Mpanduji, D.G. (1997). Serosurvey of leptospirosis in rodents, dogs and cattle in selected areas of Tanzania. Tanz Vet J 17(3): 72-75.
- Machang’u, R.S., Mgode, G. and Gisakanyi, N. (1997). Recurrent Staphylococcal Scalded Skin Syndrome in Children. Report of two cases. East Africa Med J 74 (9): 603-604.
- Machang'u, R.S.; Mgode, G.; and Kessy, A.J. (1996). Leptospirosis: A public health threat at the Morogoro slaughterhouse. Tanz Vet J 16 (2).
- Machang'u, R.S., Mgode, G. and Mpanduji, D.G. (1994). Experiences in growth and maintenance of leptospires in the laboratory. Tanz Vet J 14: 136-140.
- Mgode, G.F. Determination of Mycobacterium tuberculosis odour compounds detected by Cricetomys gambianus rats for diagnosis of pulmonary tuberculosis in low-income settings. PhD Dissertation. Max Planck Institute for Infection Biology, Berlin, Germany, and Technical University of Berlin, Berlin Germany (2011).
- Mgode, G.F. Application of a multidisciplinary approach to the systematics of Acomys (Rodentia: Muridae) from northern Tanzania. MSc. Dissertation, University of Pretoria, Pretoria, South Africa (2006).
- Mgode, G.F. Comparison of conventional phenotypic methods and molecular (genotypic) characterization of pathogenic and saprophytic leptospires. BSc. Research project. Open University of Tanzania, Dar es Salaam, Tanzania (2003).
- Epiphan Shao – 2016
- Yusuph Mahungo – 2015
- Huruma Mbugi – 2013
- Evance Nkwama – 2013
- Dickson Ndanga – 2013
- Michael Thomas – 2013
- Isaac John – 2013
- Elikunda Kimaro – Sokoine University of Agriculture
- Mungo Kisinza – University of Pretoria